One Mission: Zero Seizures.
Fédération Hospitalo-Universitaire (FHU) “Epilepsy and Disorders of Neuronal Excitability”
Central to Epinext‘s presurgical evaluation is the large-scale brain modeling and data visualization platform The Virtual Brain (TVB) which has been developed as an open-source software by Codebox. With TVB, Epinext scientists can already build a sufficiently realistic brain model from a patient‘s neuroimaging measurements (e.g. fMRI, EEG, MEG, BOLD signals). Codebox‘ team will extend the software in close collaboration with Epinext to implement novel biophysical representations of cortical sources, geometry and laminar representations.
The team of Micromed is already working with several epilepsy centers in Marseille, Grenoble and Rennes to improve SEEG (stereotaxic EEG) recordings. As the first company in Europe, they‘re developing signal amplifiers for SEEG and new software algorithms to interpret the resulting data.
Alcis offers a range of surgical devices and accessories incl. SEEG electrodes. From an ongoing collaboration with Epinext and EMSE, Alcis develops a new generation of intracerebral electrodes based on organic electronics. Because these are 100% biocompatible, they can also stay implanted for extended periods of time.
Although these new electrodes are incredibly thin, they can still record field potentials, single neurons firing and molecular signals – all in parallel. First practical usage in clinical settings has already been conducted to do presurgical evaluation in Epinext neurosurgery units.
Being the oldest elite engineering school in France, EMSE‘s bioelectronics department is collaborating with Epinext and Alcis to design and test state-of-the-art recording devices for electrophysiological and molecular brain activities. With a world-leading team of engineers, EMSE already successfully delivered salp EEG devices and is now developing organic tools for intracerebral recordings, to be built into electrodes from Alcis.
Aix en Provence/France
As a leader in the evaluation of proconvulsive profiles of active molecules in animal brain tissue, Neuroservice provides timely assays to Epinext researchers.